to medicate or not to medicateI may not know the exact effects of long-term medication. No one has yet taken Prozac for eighty years. But I certainly know the effects of nonmedication, or of going on and off medication, or trying to reduce appropriate doses to inappropriate levels—and those effects are brain damage. You start to have consequences from chronicity. You have recurrences of increasing severity, levels of distress there is no reason for you ever to experience. We would never treat diabetes or hypertension in this on-again, off-again way; why do we do it with depression? Where has this weird social pressure come from? This illness has a an eighty percent relapse rate within a year without medication, and an eighty percent wellness rate with medication. –John Greden